The Place of Transplantation in Mantle Cell Lymphoma
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چکیده
Mantle cell lymphoma (MCL) represents 6% of all cases of B-cell non-Hodgkin lymphoma (NHL) and affects approximately 4,000 persons each year in the United States.[1,2] Similar to chronic lymphocytic leukemia, MCL expresses the mature B-cell markers CD19 and CD20 and aberrantly expresses CD5, a characteristic T-cell marker.[3] These pathologic characteristics shrouded the diagnosis of MCL until the early 1990s, when the translocation of t(11;14)(q13;q32) was identified and later found to elicit deregulation of cyclin D1.[4,5] Subsequently, the immunohistochemical stain for cyclin D1 became clinically available, which allowed more reliable diagnosis of MCL.[6,7]
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Mantle Cell Lymphoma with Multiple Lymphomatous Polyposis Presenting With Intussusceptions
Mantle cell lymphoma is an aggressive type of B-cell non-Hodgkin's lymphoma that originates from small to medium sized lymphocytes located in the mantle zone of the lymph node. The gastrointestinal tract is the predominant site of extranodal involvement in the form of multiple lymphomatous polyposis. Multiple lymphomatous polyposis due to mantle cell lymphoma presenting with intussusception is ...
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